A fast computational model for the electrophysiology of the whole human heart

In this study we present a novel computational model for unprecedented simulations of the whole cardiac electrophysiology. According to heterogeneous electrophysiologic properties heart, geometry is decomposed into set coupled conductive media having different topology and electrical conductivities: (i) network slender bundles comprising fast conduction atrial network, AV–node ventricular bundles; (ii) Purkinje network; (iii) myocardium. The propagation action potential in these governed by bidomain/monodomain equations, which are discretized space using an in–house finite volume method three cell models, Courtemanche [1] myocytes, Stewart [2] Network ten Tusscher–Panfilov [3] myocytes. developed numerical correctly reproduces electrophysiology human heart healthy pathologic conditions it can be tailored optimize resynchronization therapies or invasive surgical procedures. Importantly, solver GPU–accelerated CUDA Fortran providing speedup, thus opening way systematic parametric studies uncertainty quantification analyses.